If you are having trouble deciding on a place to focus, try using Sperling's Best Places to research and compare.
Again, packing up and going not only helps you focus your job search, it shows potential employers and networking contacts how committed you are to finding work. It's easy to sit at home and send your resume out online...it's a whole other animal if you go set up shop in a new city. It's working for me, it will work for you.
Don't forget to send your resume to Mitch.Brummer@gmail.com for a critique!